Includes bibliographical references and index

"A killer virus ... an all-powerful Empress ... an encounter cloaked in secrecy. Within living memory, smallpox was a dreaded disease. Over human history it has killed untold millions. Back in the eighteenth century, as epidemics swept Europe, the first rumours emerged of an effective treatment: a mysterious method called inoculation. But a key problem remained: convincing people to accept the preventative remedy, the forerunner of vaccination. Arguments raged over risks and benefits, and public resistance ran high. As smallpox ravaged her empire and threatened her court, Catherine the Great took the momentous decision to summon the Quaker physician Tomas Dimsdale to St Petersburg to carry out a secret mission that would transform both their lives. Lucy Ward expertly unveils the extraordinary story of Enlightenment ideals, female leadership and the fight to promote science over superstition." -- Book jacket flap

A killer disease ... an all-powerful Empress ... an extraordinary encounter ... the astonishing true story. No disease sparked as much dread in the eighteenth century as smallpox. It killed children all across Europe with ruthless efficiency and those lucky enough to survive were disfigured with the tell-tale pitted scars. But a method offered hope in preventing serious infection: inoculation, the practice of inserting smallpox pustules into an open wound. Those inoculated were protected from death. Only one problem remained: convincing people to take the treatment. A pamphleteering war raged in Europe about the risks and benefits of inoculation, and public resistance ran high. Catherine the Great broke the deadlock by requesting that a young Essex doctor, Thomas Dimsdale, inoculate her. Lucy Ward expertly unveils how this extraordinary situation came about - and how it kickstarted a trend of inoculations all over Europe. This is a fascinating history of Enlightenment ideals, political intrigue, and the human quest to cure disease